The Buoniconti Fund has helped raise more than $550 million for The Miami Project to Cure Paralysis at the University of Miami Miller School of Medicine. Founded after Marc Buoniconti’s paralysis, the fund has turned the Miami Project into a global hub for spinal‑cord and neurological research. Leaders such as Dr. Barth A. Green credited the center with clinical advances now used worldwide, including nervous‑system monitoring and therapeutic hypothermia protocols. The center is also testing brain‑computer interfaces and expanding into related neurological disorders. For universities, the case shows how sustained philanthropy builds research clusters, attracts talent, and creates translational pipelines. Medical schools and research offices should note the impact of long‑term donor engagement on institutional research capacity.