Johns Hopkins University moved to reduce staffing across multiple schools and offices, laying off about 110 employees after steep declines in federal research funding, according to a university spokesperson. The cuts primarily affected administrative roles and followed earlier cost-control actions including a hiring freeze and reductions in discretionary spending. The university framed the workforce reductions as an adjustment to a shrinking federal research “portfolio.” In a statement, spokesman Doug Donovan said infrastructure around research must change in parallel as grants decline. The layoffs come as President Ron Daniels previously warned of continuing downward trends in federal support. Carey Business School is among the units affected, with Johns Hopkins also planning additional administrative budget cuts and research operational changes aimed at cost efficiency through technology and reduced duplication. The timing underscores how volatile federal funding is forcing private universities to restructure overhead even while keeping their research mission intact.