Johns Hopkins University is laying off about 110 employees after federal research spending cuts reduced grant funding. The university said the cuts are concentrated in administrative roles, following budget-savings efforts that were intended to avoid workforce reductions. The underlying financial pressure is tied to the shrinking federal portfolio: Johns Hopkins said its federal grants dropped by roughly $500 million last year, and those downward trends continued into 2026. President Ron Daniels also indicated the university will adjust infrastructure around the federal research changes. Alongside the layoffs, Johns Hopkins plans to cut 10% from its administrative budget and use technology to reduce duplication in research operations, while exploring revenue diversification through corporate research partnerships and new academic offerings.