University of Pennsylvania President Larry Jameson announced he will step down next summer, ending a tenure that began as interim leadership in 2023 and continued after Penn removed the “interim” label in 2025. Penn’s Board of Trustees chair, Ramanan Raghavendran, said the university will begin a presidential search this fall. Jameson’s leadership period included heightened scrutiny from lawmakers over campus antisemitism concerns and a high-profile dispute with the Trump administration tied to Lia Thomas and federal research funding freezes. Penn later agreed to an apology for cisgender female competitors after the administration restored federal research funding. The departure creates an inflection point for Penn governance as it moves into another leadership transition amid ongoing federal policy pressures affecting research, student policy, and campus climate. The announcement also signals that the next president will inherit both ongoing compliance obligations and reputational and political risk management for the university’s public-facing priorities.