National Institutes of Health Director Jay Bhattacharya has mandated a comprehensive review of all active and planned research funding and contracts. The directive aims to align NIH priorities with agency strategic goals, including artificial intelligence and evidence-based healthcare for transgender youth. Projects misaligned with these priorities may face restrictions or termination. The review coincides with federal efforts to re-evaluate discretionary grant allocation and follows recent political scrutiny of health research funding, signaling major operational adjustments within NIH.