University of Pennsylvania President Larry Jameson will step down next year when his contract expires next June, the university announced Friday. Jameson had served as interim in 2023 during a period of institutional crisis and removed the interim tag in 2025, with his departure now triggering a presidential search. Penn’s earlier leadership turmoil included intense scrutiny from lawmakers over campus antisemitism handling and a later clash with the Trump administration over Lia Thomas’s participation in women’s swimming and diving. The university later reached an agreement involving concessions related to affected student-athletes before federal research funding was restored. Ramanan Raghavendran, chair of Penn’s Board of Trustees, said the search will begin this fall, setting up a high-stakes leadership selection as Penn navigates ongoing federal compliance expectations and student-athlete policy concerns.