Johns Hopkins continued sector-wide workforce adjustments as federal research cuts forced additional restructuring, with a second wave of changes affecting central administration and research operations. The university confirmed it laid off about 110 employees and said the reductions reflect ongoing portfolio shrinkage rather than one-time attrition. Alongside layoffs, the institution signaled further administrative budget reductions and additional research operational changes intended to reduce cost and duplication, including use of technology. President Ron Daniels previously said grants fell sharply last year and trends carried into 2026. The move adds to broader pressure on both private and public research universities as federal funding uncertainty affects staffing models, administrative overhead, and long-term research infrastructure planning.